Why do researchers want well-being to count as a clinical-trial endpoint, and how could this change psychedelic research? TLDR: •A 2026 npj Mental Health Research Perspective makes a proposal. •It says well-being may be a co-primary endpoint. •Trials should not track only symptom drops. •Patients...
What did the first publicly funded UK randomized psilocybin trial find, and why should readers interpret the results with care? TLDR: •A UK trial included 60 people with treatment-resistant depression. •One group received one 25 mg psilocybin session. •The other group received a true placebo....
What does new neuroimmune research suggest about rapid antidepressant response, and what does it not yet prove? TLDR: •New research suggests shared immune-to-brain signals may matter. •Ketamine and some serotonergic psychedelics start at different receptors. •Yet their later pathways may overlap in some ways. •In...
Psilocybin may link with short-term gains in some groups. These gains involve attention and flexible thinking. The review did not show a sure benefit for all. The studies were small, early, and uneven. (1, 2) Psilocybin is a compound found in some mushrooms. Cognitive flexibility...