Key Points •Psychedelic experiences often induce profound feelings of awe and boundary dissolution that can permanently alter a person's worldview. •A 2026 study in npj Mental Health Research found that these experiences catalyze "epistemic shifts"—fundamental changes in how individuals understand themselves and the world. •Participants...
Key Points •A large-scale study in Switzerland provides strong real-world evidence for the effectiveness of psychedelic-assisted psychotherapy. •Patients with treatment-resistant depression and anxiety showed significant symptom reduction after treatment. •Both LSD and psilocybin were found to be comparably effective and safe in a routine clinical...
Key Points •The powerful psychedelic 5-MeO-DMT induces a unique brain state that resembles deep sleep, even while the user is behaviorally awake. •Scientists have named this phenomenon “paradoxical wake,” a nod to the similarly paradoxical nature of REM sleep. •This state involves a profound disconnection...
Key Points •Alzheimer's disease involves not just genetics, but also “epigenetic” changes that control how genes function. •Serotonergic psychedelics like psilocybin and LSD are being studied for their ability to promote neuroplasticity and reduce neuroinflammation. •Emerging research suggests psychedelics can modulate epigenetic mechanisms, potentially correcting...